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This is the first study to evaluate the safety and viral shedding of LAIV in Chinese healthy juveniles and adults. LAIV has many advantages. LAIV imitates natural infection, stimulating mucosal and humoral immunity without causing severe illness. LAIV was produced by growing attenuated influenza viruses in chick embryo cells . These attenuated ...

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Effectiveness of the quadrivalent live attenuated influenza vaccine ...

LAIV vaccinations consisted of a temperature-sensitive (ts) attenuated variant of HK/Syd, HK/Syd att/ts (LAIV) that contains site-specific mutations in the PB1 and PB2 RNA segments of the genome (see Fig. S1 in the supplemental material) as described previously .

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Update: ACIP Recommendations for the Use of Quadrivalent Live...

Background: Live attenuated influenza vaccine (LAIV) might increase the risk of wheezing in persons with asthma or children younger than 5 years with a history of recurrent wheezing. Objective: To describe the use and assess the safety of LAIV in persons with asthma in the Vaccine Safety Datalink population.